Living Organisms
Cayman Chemical Pemetrexed sodium salt hydra
An antifolate with anticancer activity; an inhibitor of thymidylate synthase and dihydrofolate reductase (Kis = 109 and 7 nM, respectively); has increased potency for thymidylate kinase when polyglutaminated (Ki = 1.3 nM); an inhibitor of glycinamide ribonucleotide formyltransferase (Kis = 9,300 and 65 nM for the non-glutaminated and polyglutaminated enzyme) and aminoimidazole carboxamide ribonucleotide formyltransferase (Kis = 3,600 and 265 nM for the non-glutaminated and polyglutaminated, respectively); inhibits proliferation of CCRF-CEM cells but not 5,10-dideazatetrahydrofolate-resistant CR15 cells (IC50s = 0.254 and 200 µM, respectively); reduces tumor growth in A549, H1299, and PC-9 NSCLC mouse xenograft models but not in models using the same cell lines overexpressing thymidylate kinase
Cayman Chemical FrovatrIptnsuccInAT hydra 10mg
An agonist of 5-HT1B and 5-HT1D receptors (Kis = 2.51 and 3.98 nM, respectively); selective for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2C, 5-HT3, and 5-HT7 receptors, as well as dopamine D1, D2, and D3, histamine H1, and α1-adrenergic receptors (Kis = >50 nM); induces contractions in human basilar arteries isolated post-mortem, coronary arteries from transplant recipient hearts, and coronary arteries from donor hearts unsuitable for transplantation (EC50s = 13.8, 41.69, and 15.49 nM, respectively); increases carotid vascular resistance in closed-chest and open-chest anesthetized dogs (ED50s = 6 and 1 nmol/kg, i.v., respectively)
Medchemexpress LLC ANTS | 5398-34-5 | 99.1% | 100 MG
ANTS is a fluorescent dye utilized for measuring membrane leakage. It has an excitation wavelength of 380 nm and an emission wavelength of 520 nm. When encapsulated in liposomes with DPX, ANTS provides an effective method for assessing membrane permeability.
- Solid appearance, white to off-white color.
- Store at 4°C, protected from light.
- When in solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light.
- Soluble in DMSO at 20 mg/mL (46.80 mM) with ultrasonic, warming, and heating to 80°C.
Cayman Chemical A943931hydroCLOrID hydra 10mg
A histamine H4 receptor antagonist (Ki = 3.8 nM); inhibits clobenpropit-induced scratching in mice (ED50 = 26 µmoles/kg, i.p.)
MSC J.T. Eaton Live Catch Trap, 10.5 x 3.75 x 2 in, Window
The J.T. Eaton Live Catch Trap is designed for the humane capture of pests. It features a compact size and includes a window for easy viewing.
- Live catch trap
- Includes a window
Uline Teknor Apex Neverkink Xp Garden Hose - Industrial Plus, 50', 3/4” Diameter
Teknor Apex NeverkinkXp Garden Hose-Industrial Plus 50FT 3/4 Diameter
Cayman Chemical Cefotiam hydrochloride hydra
A broad-spectrum cephalosporin antibiotic; inhibits the growth of S. aureus (MIC50 = 0.26 UG/ml), as well as P. aeruginosa, E. coli, and H. influenzae (MIC50s = 1, 0.06, and 0.01 UG/ml, respectively); increases survival in mouse models of infection with strains of S. aureus (ED50s = 3.5 and 8.3 mg/kg) and E. coli (ED50s = 0.5-25 mg/kg)
Medchemexpress LLC ANTS | 5398-34-5 | 99.1% | 25 MG
ANTS is a fluorescent dye with an excitation wavelength of 380 nm and an emission wavelength of 520 nm. When encapsulated with DPX in liposomes, ANTS can be used as an effective method for measuring membrane leakage.
- Fluorescent dye for cell staining analysis
- Used as a membrane dye
- Excitation wavelength: 380 nm
- Emission wavelength: 520 nm
- Can measure membrane leakage when encapsulated with DPX in liposomes
Cayman Chemical MetIxenhydrochLRIde hydra 10mg
A muscarinic acetylcholine receptor antagonist (Ki = 15 nM for the rat receptor); inhibits bovine AChE by 43% at 10 µM and BChE (IC50 = 1.6 µM for the horse enzyme) in cell-free assays; reduces the proliferation of P388 and P388/ADR leukemia cells (EC50s = 10 and 12 µM, respectively); induces apoptosis in BT474 and MDA-MB-231 cancer cells at 15 µM and induces autophagy in the same cells at 10 µM; decreases tumor weight and volume and improves survival in an MDA-MB-231 breast cancer mouse xenograft model at 1 mg/kg three times per week
AdipoGen ANTS
Chemical. CAS 5398-34-5. Formula C10H7NNa2O9S3. Molecular Weight 427.34. ANTS is a highly negatively charged dye with an amino group that can be coupled to an aldehyde or ketone group to form an unstable Schiff base. The Schiff base is usually chemically reduced by sodium borohydride NaBH4 or sodium cyanoborohydride NaBCNH3 to form a stable linkage. This labeling technique has been widely used for the labeling and subsequent sequencing of oligosaccharides and glycoproteins. The negative charges of the dye facilitate the electrophoretic separation of the degradation products of carbohydrate polymers. The polyanionic dye ANTS is used together with the fluorescent cationic quencher DPX for membrane fusion studies or permeability assays. The mixture of ANTS-DPX is minimally fluorescent initially, but becomes increasingly more fluorescent upon dilution i.e. membrane fusion or leakage. ANTS also is used as a neuronal tracer.
Cayman Chemical BIX01294hydrochLRIde hydra 1mg
A selective inhibitor of G9a histone methyltransferase (IC50 = 1.7 μM); less effectively inhibits G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known histone methyltransferases
Cayman Chemical MetIxenhydrochlorIde hydra 5mg
A muscarinic acetylcholine receptor antagonist (Ki = 15 nM for the rat receptor); inhibits bovine AChE by 43% at 10 µM and BChE (IC50 = 1.6 µM for the horse enzyme) in cell-free assays; reduces the proliferation of P388 and P388/ADR leukemia cells (EC50s = 10 and 12 µM, respectively); induces apoptosis in BT474 and MDA-MB-231 cancer cells at 15 µM and induces autophagy in the same cells at 10 µM; decreases tumor weight and volume and improves survival in an MDA-MB-231 breast cancer mouse xenograft model at 1 mg/kg three times per week